write_enrich_results_xlsx

Exports the results from `pathway_vote` to a multi-sheet Excel file.
Validates that the input is a list, checks for the `openxlsx` package, and handles sheet naming
to comply with Excel limitations.

Performs pathway enrichment analysis using a voting-based framework that integrates CpG–gene regulatory information from expression quantitative trait methylation (eQTM) data. For a grid of top-ranked CpGs and filtering thresholds, gene sets are generated and refined using an entropy-based pruning strategy that balances information richness, stability, and probe bias correction. In particular, gene lists dominated by genes with disproportionately high numbers of CpG mappings are penalized to mitigate active probe bias—a common artifact in methylation data analysis. Enrichment results across parameter combinations are then aggregated using a voting scheme, prioritizing pathways that are consistently recovered under diverse settings and robust to parameter perturbations.

Yinan Zheng

PathwayVote

Robust Pathway Enrichment for DNA Methylation Studies Using
Ensemble Voting

write_enrich_results_xlsx function

<dl><dt>results</dt>
<dd>A named list of data.frames (e.g., output from `pathway_vote`).</dd>
<dt>file</dt>
<dd>Character. Output file path (e.g., "enrich_results.xlsx").</dd></dl>

Arguments

Export Enrichment Results to Excel — write_enrich_results_xlsx

<dl>

<dt>results</dt>
<dd>A named list of data.frames (e.g., output from `pathway_vote`).</dd>


<dt>file</dt>
<dd>Character. Output file path (e.g., "enrich_results.xlsx").</dd>

</dl>

write_enrich_results_xlsx: Export Enrichment Results to Excel

Description

Usage

Value

Arguments

Examples