PharmacoGx (version 1.1.6)

computeABC: Fits dose-response curves to data given by the user and returns the ABC of the fitted curves.

Description

Fits dose-response curves to data given by the user and returns the ABC of the fitted curves.

Usage

computeABC(conc1, conc2, viability1, viability2, trunc = TRUE)

Arguments

conc1

[vector] is a vector of drug concentrations.

conc2

[vector] is a vector of drug concentrations.

viability1

[vector] is a vector whose entries are the viability values observed in the presence of the drug concentrations whose logarithms are in the corresponding entries of conc1, expressed as percentages of viability in the absence of any drug.

viability2

[vector] is a vector whose entries are the viability values observed in the presence of the drug concentrations whose logarithms are in the corresponding entries of conc2, expressed as percentages of viability in the absence of any drug.

trunc

[logical], if true, causes viability data to be truncated to lie between 0 and 1 before curve-fitting is performed.

Examples

dose1 <- c("0.0025","0.008","0.025","0.08","0.25","0.8","2.53","8") 
viability1 <- c("108.67","111","102.16","100.27","90","87","74","57")
dose2 <- c("0.0025","0.008","0.025","0.08","0.25","0.8","2.53","8") 
viability2 <- c("100.94","112.5","86","104.16","75","68","48","29")
computeABC(dose1, dose2, viability1, viability2)