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PlatformDesign (version 2.1.4)

Optimal Two-Period Multiarm Platform Design with New Experimental Arms Added During the Trial

Description

Design parameters of the optimal two-period multiarm platform design (controlling for either family-wise error rate or pair-wise error rate) can be calculated using this package, allowing pre-planned deferred arms to be added during the trial. More details about the design method can be found in the paper: Pan, H., Yuan, X. and Ye, J. (2022) "An optimal two-period multiarm platform design with new experimental arms added during the trial". Manuscript submitted for publication. For additional references: Dunnett, C. W. (1955) .

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Version

Install

install.packages('PlatformDesign')

Monthly Downloads

190

Version

2.1.4

License

GPL (>= 3)

Maintainer

Xiaomeng Yuan

Last Published

December 15th, 2022

Functions in PlatformDesign (2.1.4)

PlatformDesign-package

PlatformDesign: Optimal Two-Period Multiarm Platform Design with New Experimental Arms Added During the Trial
one_stage_multiarm

Calculate the sample sizes and other design parameters for an one-stage K-experimental arm trial using the root-K rule for the allocation ratio, controlling for FWER or PWER
platform_design

Design an optimal two-period multiarm platform trial with new experimental arms added during the trial, controlling for FWER or PWER
platform_design2

A faster version of platform_design()
one_design

Calculate other design parameters of a two-period K+M-experimental arm platform design given sample sizes
fwer_critical

Calculate the critical value and the marginal type-I error rate
admiss

Find the admissible set in a two-period K+M-experimental arm platform design with delayed arms
cor.mat

Calculate the correlation matrix of the z-statistics for a two-period K+M-experimental arm platform design with delayed arms