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PoolBal (version 0.1-0)

Balancing Central and Marginal Rejection of Pooled p-Values

Description

When using pooled p-values to adjust for multiple testing, there is an inherent balance that must be struck between rejection based on weak evidence spread among many tests and strong evidence in a few, explored in Salahub and Olford (2023) . This package provides functionality to compute marginal and central rejection levels and the centrality quotient for p-value pooling functions and provides implementations of the chi-squared quantile pooled p-value (described in Salahub and Oldford (2023)) and a proposal from Heard and Rubin-Delanchy (2018) to control the quotient's value.

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Version

Install

install.packages('PoolBal')

Monthly Downloads

177

Version

0.1-0

License

GPL (>= 3)

Maintainer

Chris Salahub

Last Published

November 22nd, 2023

Functions in PoolBal (0.1-0)

hrPr

Empirical UMP beta marginal rejection level
marHistHeatMap

Heatmap with marginal histograms
hrStat

UMP beta p-value pooled statistic
hrQ

Empirical UMP beta centrality quotient
satterChiPool

Pool p-values using the Satterthwaite approximation
satterApproxP

Satterthwaite p-values
chiPc

Chi-squared central rejection level
chiKappa

Chi-squared kappa for a given centrality quotient
betaDiv

Compute the Kullback-Leibler divergence between the beta and uniform distributions
altFrequencyMat

Identify a region of plausible alternative hypotheses in the proportion, strength of non-null evidence space
rBetaH4

Generate realizations of beta alternative distributions
klDiv

Compute the Kullback-Leibler divergence
estimatePrb

Compute the marginal rejection level
estimateQ

Compute the centrality quotient
chiQ

Chi-squared centrality quotient
chiPr

Chi-squared marginal rejection level
chiPool

Chi-squared p-value pooling
hrPool

Empirical UMP beta pooled p-value
convertGeneticSigma

Convert p-value correlation to chi-squared covariance
findA

Estimate parameter for a given beta KL divergence and UMP test
estimatePc

Compute the central rejection level
hrPc

Empirical UMP beta central rejection level