Compute the FIM for one individual given specific model(s), parameters, design and methods.

internal

Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix. This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems. The methods are described in Nyberg et al.
(2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004)
<doi:10.1016/S0169-2607(03)00073-7>.

Andrew C. Hooker

PopED

Population (and Individual) Optimal Experimental Design

Marco Foracchia

Eric Stroemberg

Martin Fink

Giulia Lestini

Sebastian Ueckert

Joakim Nyberg

mf3 function

<dl><dt>model_switch</dt>
<dd>A vector that is the same size as xt, specifying which model each sample belongs to.</dd>
<dt>xt</dt>
<dd>A vector of sample times.</dd>
<dt>x</dt>
<dd>A vector for the discrete design variables.</dd>
<dt>a</dt>
<dd>A vector of covariates.</dd>
<dt>bpop</dt>
<dd>The fixed effects parameter values. Supplied as a vector.</dd>
<dt>d</dt>
<dd>A between subject variability matrix (OMEGA in NONMEM).</dd>
<dt>sigma</dt>
<dd>A residual unexplained variability matrix (SIGMA in NONMEM).</dd>
<dt>docc</dt>
<dd>A between occasion variability matrix.</dd>
<dt>poped.db</dt>
<dd>A PopED database.</dd></dl>

Arguments

The Fisher Information Matrix (FIM) for one individual — mf3

<dl>

<dt>model_switch</dt>
<dd>A vector that is the same size as xt, specifying which model each sample belongs to.</dd>


<dt>xt</dt>
<dd>A vector of sample times.</dd>


<dt>x</dt>
<dd>A vector for the discrete design variables.</dd>


<dt>a</dt>
<dd>A vector of covariates.</dd>


<dt>bpop</dt>
<dd>The fixed effects parameter values. Supplied as a vector.</dd>


<dt>d</dt>
<dd>A between subject variability matrix (OMEGA in NONMEM).</dd>


<dt>sigma</dt>
<dd>A residual unexplained variability matrix (SIGMA in NONMEM).</dd>


<dt>docc</dt>
<dd>A between occasion variability matrix.</dd>


<dt>poped.db</dt>
<dd>A PopED database.</dd>

</dl>

mf3: The Fisher Information Matrix (FIM) for one individual

Description

Usage

Value

Arguments

See Also