Power2Stage v0.5.2

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Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Contains functions to obtain the operational characteristics of bioequivalence studies with 2-stage designs (TSD) via simulations.

Functions in Power2Stage

Name Description
sampleN2.TOST Sample size re-estimation of adaptive 2-stage BE studies in 2x2 crossover and parallel designs based on power of TOST
power.tsd.ssr Power of 2-stage BE studies in 2x2 crossover designs with interim sample size re-estimation
power.tsd.GS Power calculation for non-adaptive group sequential (2-stage) BE studies
power.tsd.p Power calculation of adaptive 2-stage BE studies in 2-group parallel designs
power.tsd.in Power calculation of adaptive 2-stage BE studies with 2x2 crossover design, based on the Inverse Normal method
power.tsd.KM Power calculation of adaptive 2-stage BE studies (2x2 crossover) (variant of power.2stage to obtain the results of Karalis / Macheras)
power.tsd.fC Power calculation of adaptive 2-stage BE studies (2x2 crossover) with a futility criterion for the point estimate of T/R or its 90% CI
power.tsd Power calculation of adaptive 2-stage BE studies in a 2x2 crossover design
final.tsd.in Analysis after second stage of 2-stage 2x2 crossover design based on the Inverse Normal method
interim.tsd.in Interim analysis of first stage data of 2-stage 2x2 crossover designs based on the Inverse Normal method
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Details

Encoding UTF-8
Type Package
Date 2019-04-21
ByteCompile yes
URL https://github.com/Detlew/Power2Stage
BugReports https://github.com/Detlew/Power2Stage/issues
License GPL (>= 2)
LazyLoad yes
LazyData yes
NeedsCompilation no
Packaged 2019-04-20 19:03:18 UTC; Detlew
Repository CRAN
Date/Publication 2019-04-20 19:30:03 UTC

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