Power2Stage v0.5.2

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Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies

Contains functions to obtain the operational characteristics of bioequivalence studies with 2-stage designs (TSD) via simulations.

Functions in Power2Stage

 Name Description sampleN2.TOST Sample size re-estimation of adaptive 2-stage BE studies in 2x2 crossover and parallel designs based on power of TOST power.tsd.ssr Power of 2-stage BE studies in 2x2 crossover designs with interim sample size re-estimation power.tsd.GS Power calculation for non-adaptive group sequential (2-stage) BE studies power.tsd.p Power calculation of adaptive 2-stage BE studies in 2-group parallel designs power.tsd.in Power calculation of adaptive 2-stage BE studies with 2x2 crossover design, based on the Inverse Normal method power.tsd.KM Power calculation of adaptive 2-stage BE studies (2x2 crossover) (variant of power.2stage to obtain the results of Karalis / Macheras) power.tsd.fC Power calculation of adaptive 2-stage BE studies (2x2 crossover) with a futility criterion for the point estimate of T/R or its 90% CI power.tsd Power calculation of adaptive 2-stage BE studies in a 2x2 crossover design final.tsd.in Analysis after second stage of 2-stage 2x2 crossover design based on the Inverse Normal method interim.tsd.in Interim analysis of first stage data of 2-stage 2x2 crossover designs based on the Inverse Normal method No Results!