Power2Stage v0.5.2
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Power and Sample-Size Distribution of 2-Stage Bioequivalence Studies
Contains functions to obtain the operational characteristics of
bioequivalence studies with 2-stage designs (TSD) via simulations.
Functions in Power2Stage
| Name | Description | |
| sampleN2.TOST | Sample size re-estimation of adaptive 2-stage BE studies in 2x2 crossover and parallel designs based on power of TOST | |
| power.tsd.ssr | Power of 2-stage BE studies in 2x2 crossover designs with interim sample size re-estimation | |
| power.tsd.GS | Power calculation for non-adaptive group sequential (2-stage) BE studies | |
| power.tsd.p | Power calculation of adaptive 2-stage BE studies in 2-group parallel designs | |
| power.tsd.in | Power calculation of adaptive 2-stage BE studies with 2x2 crossover design, based on the Inverse Normal method | |
| power.tsd.KM | Power calculation of adaptive 2-stage BE studies (2x2 crossover) (variant of power.2stage to obtain the results of Karalis / Macheras) | |
| power.tsd.fC | Power calculation of adaptive 2-stage BE studies (2x2 crossover) with a futility criterion for the point estimate of T/R or its 90% CI | |
| power.tsd | Power calculation of adaptive 2-stage BE studies in a 2x2 crossover design | |
| final.tsd.in | Analysis after second stage of 2-stage 2x2 crossover design based on the Inverse Normal method | |
| interim.tsd.in | Interim analysis of first stage data of 2-stage 2x2 crossover designs based on the Inverse Normal method | |
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Details
| Encoding | UTF-8 |
| Type | Package |
| Date | 2019-04-21 |
| ByteCompile | yes |
| URL | https://github.com/Detlew/Power2Stage |
| BugReports | https://github.com/Detlew/Power2Stage/issues |
| License | GPL (>= 2) |
| LazyLoad | yes |
| LazyData | yes |
| NeedsCompilation | no |
| Packaged | 2019-04-20 19:03:18 UTC; Detlew |
| Repository | CRAN |
| Date/Publication | 2019-04-20 19:30:03 UTC |
| imports | cubature , mvtnorm , PowerTOST , stats |
| suggests | graphics |
| Contributors | Helmut Schuetz, Benjamin Lang |
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