PowerTOST (version 1.4-7)

ctSJ.VIII.10+ctSJ.VIII.20+ctCW.III: Sample Size Tables for the Parallel Group Design

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the parallel group design (2 groups).

Details

The data.frames can be accessed by their names.

ctSJ.VIII.10 is Table VIII, column ‘level of bioequivalence 10%’ from Julious SA. Tutorial in Biostatistics. Sample sizes for clinical trials with Normal data. Stat Med. 2004;23(12):1921--86. 10.1002/sim.1783

Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), target power=90%, power approximate via non-central t-distribution. Attention! Julious gives sample size per group.

ctSJ.VIII.20 is Table VIII from the same source column ‘level of bioequivalence 20%’ Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), target power=90%, power approximate via non-central t.

ctCW.III is Table III from Chow SC, Wang H. On Sample Size Calculation in Bioequivalence Trials J Pharmacokinet Pharmacodyn. 2001. 28(2):155--69. Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact.

Seems the last reference is not very reliable (compare to the Table in the paper).

Examples

# NOT RUN {
ctSJ.VIII.10
ctSJ.VIII.20
ctCW.III
# }