PowerTOST (version 1.4-9)

bib.CL: Design matrices of period balanced incomplete block designs

Description

This function returns the ‘design’ matrix of incomplete block designs described by Chow & Liu. The design matrices were recoded 1=R, 2=T1, 3=T2, …

Usage

bib.CL(trt, p)

Arguments

trt

Number of treatments (3 to 5).

p

Number of periods (2 to trt-1).

Value

Matrix containing the sequences in rows and periods in columns. The entry (i, j) of the matrix corresponds to the treatment or dose (index) a subject within i-th sequence gets in the j-th period.

References

Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. Boca Raton: CRC Press; 3 edition 2009. Chapter 2.6.

Examples

# NOT RUN {
# 4 treatments/doses, 3 periods
bib.CL(4, 3)
# gives 4 sequences
# to see this in Chow & Liu's coding
tmt <- c("R", "T1", "T2", "T3")
matrix(tmt[bib.CL(4, 3)], ncol=3)
# }