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PwrGSD (version 2.3.1)

Power in a Group Sequential Design

Description

Tools for the evaluation of interim analysis plans for sequentially monitored trials on a survival endpoint; tools to construct efficacy and futility boundaries, for deriving power of a sequential design at a specified alternative, template for evaluating the performance of candidate plans at a set of time varying alternatives. See Izmirlian, G. (2014) .

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Version

Install

install.packages('PwrGSD')

Monthly Downloads

462

Version

2.3.1

License

GPL (>= 2)

Maintainer

Grant Izmirlian

Last Published

April 15th, 2019

Functions in PwrGSD (2.3.1)

Haybittle

The Haybittle method of Boundary Construction
RR2RCM

Relative risk to Relative Cumulative Mortality
Power

Extract the Power results
Elements

Create a subset of a "cpd.PwrGSD" object
PwrGSD

Calculate Power in a Group Sequential Design
LanDemets

The Lan-Demets method of Boundary Construction
CRRtoRR

Cumulative-risk ratios to risk ratios
plot.cpd.PwrGSD

Plot Method for cpd.PwrGSD objects
CDFOR2LRR

Convert CDF Odds Ratio to Logged Relative Risks
CY2TOShaz

Calender year rates to Study Year Rates
ObrienFleming

The O'Brien-Fleming Alpha Spending Function
as.boundaries

Convert a "PwrGSD" object to a "boundaries" object
RCM2RR

Relative cumulative mortality to Relative Risk
lookup

Lookup values for a piecewise constant function
GrpSeqBnds

Computes efficacy and futility boundaries
Pow

The Wang-Tsiatis Power Alpha Spending Function
SimGSB

Verifies the results of "GrpSeqBnds" via simulation
wtdlogrank

Weighted log-rank test
lung

Mayo Clinic Lung Cancer Data
CondPower

Conditional type I and type II error probabilities given current value of the test statistic
gsd.dens

A function for computing the probability density for the group sequentially monitored test statistic.
DX

A utility function for forming differences
EX1gXK

A function for computing the bias adjusted point estimate for a statistic observed to cross the efficacy boundary.
IntSurvDiff

Weighted Integrated Survival function test
agghaz

Aggregated Hazard
paste

The paste operator
SCtoBdry

Converts a stochastic curtailment boundary (conditional type I or II error probability) into a (efficacy or futility) boundary on the standardized Z scale
cpd.PwrGSD

Create a skeleton compound PwrGSD object
mysurvfit

My Survfit
Pocock

The Pocock Alpha Spending Function
SC

The Stochastic Curtailment method of Boundary Construction
mystack

Stack a dataset