PwrGSD v2.3.1

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by Grant Izmirlian View Source

Power in a Group Sequential Design

Tools for the evaluation of interim analysis plans for sequentially monitored trials on a survival endpoint; tools to construct efficacy and futility boundaries, for deriving power of a sequential design at a specified alternative, template for evaluating the performance of candidate plans at a set of time varying alternatives. See Izmirlian, G. (2014) <doi:10.4310/SII.2014.v7.n1.a4>.

Functions in PwrGSD

Name	Description
Haybittle	The Haybittle method of Boundary Construction
RR2RCM	Relative risk to Relative Cumulative Mortality
Power	Extract the Power results
Elements	Create a subset of a "cpd.PwrGSD" object
PwrGSD	Calculate Power in a Group Sequential Design
LanDemets	The Lan-Demets method of Boundary Construction
CRRtoRR	Cumulative-risk ratios to risk ratios
plot.cpd.PwrGSD	Plot Method for cpd.PwrGSD objects
CDFOR2LRR	Convert CDF Odds Ratio to Logged Relative Risks
CY2TOShaz	Calender year rates to Study Year Rates
ObrienFleming	The O'Brien-Fleming Alpha Spending Function
as.boundaries	Convert a "PwrGSD" object to a "boundaries" object
RCM2RR	Relative cumulative mortality to Relative Risk
lookup	Lookup values for a piecewise constant function
GrpSeqBnds	Computes efficacy and futility boundaries
Pow	The Wang-Tsiatis Power Alpha Spending Function
SimGSB	Verifies the results of "GrpSeqBnds" via simulation
wtdlogrank	Weighted log-rank test
lung	Mayo Clinic Lung Cancer Data
CondPower	Conditional type I and type II error probabilities given current value of the test statistic
gsd.dens	A function for computing the probability density for the group sequentially monitored test statistic.
DX	A utility function for forming differences
EX1gXK	A function for computing the bias adjusted point estimate for a statistic observed to cross the efficacy boundary.
IntSurvDiff	Weighted Integrated Survival function test
agghaz	Aggregated Hazard
paste	The paste operator
SCtoBdry	Converts a stochastic curtailment boundary (conditional type I or II error probability) into a (efficacy or futility) boundary on the standardized Z scale
cpd.PwrGSD	Create a skeleton compound PwrGSD object
mysurvfit	My Survfit
Pocock	The Pocock Alpha Spending Function
SC	The Stochastic Curtailment method of Boundary Construction
mystack	Stack a dataset
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Vignettes of PwrGSD

Name
GrpSeqBnds-vignette.Rnw
PwrGSD-vignette.Rnw
cpd-PwrGSD-vignette.Rnw
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Details

License	GPL (>= 2)
NeedsCompilation	yes
Packaged	2019-04-15 20:43:59 UTC; izmirlig
Repository	CRAN
Date/Publication	2019-04-15 21:22:51 UTC

depends	survival
Contributors	Grant Izmirlian