# PwrGSD v2.3.1

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## Power in a Group Sequential Design

Tools for the evaluation of interim analysis plans for sequentially
monitored trials on a survival endpoint; tools to construct efficacy and
futility boundaries, for deriving power of a sequential design at a specified
alternative, template for evaluating the performance of candidate plans at a
set of time varying alternatives. See Izmirlian, G. (2014) <doi:10.4310/SII.2014.v7.n1.a4>.

## Functions in PwrGSD

Name | Description | |

Haybittle | The Haybittle method of Boundary Construction | |

RR2RCM | Relative risk to Relative Cumulative Mortality | |

Power | Extract the Power results | |

Elements | Create a subset of a "cpd.PwrGSD" object | |

PwrGSD | Calculate Power in a Group Sequential Design | |

LanDemets | The Lan-Demets method of Boundary Construction | |

CRRtoRR | Cumulative-risk ratios to risk ratios | |

plot.cpd.PwrGSD | Plot Method for cpd.PwrGSD objects | |

CDFOR2LRR | Convert CDF Odds Ratio to Logged Relative Risks | |

CY2TOShaz | Calender year rates to Study Year Rates | |

ObrienFleming | The O'Brien-Fleming Alpha Spending Function | |

as.boundaries | Convert a "PwrGSD" object to a "boundaries" object | |

RCM2RR | Relative cumulative mortality to Relative Risk | |

lookup | Lookup values for a piecewise constant function | |

GrpSeqBnds | Computes efficacy and futility boundaries | |

Pow | The Wang-Tsiatis Power Alpha Spending Function | |

SimGSB | Verifies the results of "GrpSeqBnds" via simulation | |

wtdlogrank | Weighted log-rank test | |

lung | Mayo Clinic Lung Cancer Data | |

CondPower | Conditional type I and type II error probabilities given current value of the test statistic | |

gsd.dens | A function for computing the probability density for the group sequentially monitored test statistic. | |

DX | A utility function for forming differences | |

EX1gXK | A function for computing the bias adjusted point estimate for a statistic observed to cross the efficacy boundary. | |

IntSurvDiff | Weighted Integrated Survival function test | |

agghaz | Aggregated Hazard | |

paste | The paste operator | |

SCtoBdry | Converts a stochastic curtailment boundary (conditional type I or II error probability) into a (efficacy or futility) boundary on the standardized Z scale | |

cpd.PwrGSD | Create a skeleton compound PwrGSD object | |

mysurvfit | My Survfit | |

Pocock | The Pocock Alpha Spending Function | |

SC | The Stochastic Curtailment method of Boundary Construction | |

mystack | Stack a dataset | |

No Results! |

## Vignettes of PwrGSD

Name | ||

GrpSeqBnds-vignette.Rnw | ||

PwrGSD-vignette.Rnw | ||

cpd-PwrGSD-vignette.Rnw | ||

No Results! |

## Last month downloads

## Details

License | GPL (>= 2) |

NeedsCompilation | yes |

Packaged | 2019-04-15 20:43:59 UTC; izmirlig |

Repository | CRAN |

Date/Publication | 2019-04-15 21:22:51 UTC |

depends | survival |

Contributors | Grant Izmirlian |

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