DBCD_GAUSSIAN_raw

Allocates patients to one of treatments based on doubly adaptive
biased coin design on summarized data.

Provides functions and command-line user interface to generate allocation sequence
by response-adaptive randomization for clinical trials. The package currently supports
two families of frequentist response-adaptive randomization procedures, Doubly Adaptive
Biased Coin Design ('DBCD') and Sequential Estimation-adjusted Urn Model ('SEU'), for
binary and normal endpoints. One-sided proportion (or mean) difference and Chi-square
(or 'ANOVA') hypothesis testing methods are also available in the package to facilitate
the inference for treatment effect. Additionally, the package provides comprehensive and
efficient tools to allow one to evaluate and compare the performance of randomization
procedures and tests based on various criteria. For example, plots for relationship among
assumed treatment effects, sample size, and power are provided. Five allocation functions
for 'DBCD' and six addition rule functions for 'SEU' are implemented to target allocations
such as 'Neyman', 'Rosenberger' Rosenberger et al. (2001)
<doi:10.1111/j.0006-341X.2001.00909.x> and 'Urn' allocations.

Xiu Huang

RARfreq

Response Adaptive Randomization with 'Frequentist' Approaches

Mengjia Yu

Feifang Hu

Li Wang

Hongjian Zhu

DBCD_GAUSSIAN_raw function

<dl><dt>X.df</dt>
<dd>A data frame of two columns: treatment arm and response value.</dd>
<dt>group_allo</dt>
<dd>An integer of the size of group allocation. The default is
1.</dd>
<dt>rho_func_index</dt>
<dd>Supply a number of 1, 2 or 3 indicting the
allocation function to use. (TODO: add reference)
1 = Zhang-Rosenberger allocation;
2 = Neyman allocation.
The default is 2.</dd>
<dt>rho_func</dt>
<dd>Supply a user-specified allocation function of Mean_RK and
SD_RK when rho_func_index is NULL. Default is NULL.</dd>
<dt>alpha</dt>
<dd>Supply a number indicating the subscripts of the probability
function. The default is 2. huAsymptoticPropertiesDoubly2004RARfreq</dd></dl>

Arguments

Doubly Adaptive Biased Coin Design (Gaussian Responses) — DBCD_GAUSSIAN_raw

<dl>

<dt>X.df</dt>
<dd>A data frame of two columns: treatment arm and response value.</dd>


<dt>group_allo</dt>
<dd>An integer of the size of group allocation. The default is
1.</dd>


<dt>rho_func_index</dt>
<dd>Supply a number of 1, 2 or 3 indicting the
allocation function to use. (TODO: add reference)
1 = Zhang-Rosenberger allocation;
2 = Neyman allocation.
The default is 2.</dd>


<dt>rho_func</dt>
<dd>Supply a user-specified allocation function of Mean_RK and
SD_RK when rho_func_index is NULL. Default is NULL.</dd>


<dt>alpha</dt>
<dd>Supply a number indicating the subscripts of the probability
function. The default is 2. huAsymptoticPropertiesDoubly2004RARfreq</dd>

</dl>

DBCD_GAUSSIAN_raw: Doubly Adaptive Biased Coin Design (Gaussian Responses)

Description

Usage

Value

Arguments

Details

References

Examples