sdY.est

Estimate trait standard deviation given vectors of variance of coefficients, MAF and sample size

Quickly computes polygenic scores from GWAS summary statistics of either case-control or quantitative traits without parameter tuning. Reales,G., Vigorito, E., Kelemen,M., Wallace,C. (2021) <doi:10.1101/2020.07.24.220392> "RápidoPGS: A rapid polygenic score calculator for summary GWAS data without a test dataset".

Guillermo Reales

RapidoPGS

A Fast and Light Package to Compute Polygenic Risk Scores

Chris Wallace

Olly Burren

sdY.est function

<dl><dt>vbeta</dt>
<dd>vector of variance of coefficients</dd>
<dt>maf</dt>
<dd>vector of MAF (same length as vbeta)</dd>
<dt>n</dt>
<dd>sample size</dd></dl>

Arguments

Author

Estimate trait variance, internal function — sdY.est

<dl>

<dt>vbeta</dt>
<dd>vector of variance of coefficients</dd>


<dt>maf</dt>
<dd>vector of MAF (same length as vbeta)</dd>


<dt>n</dt>
<dd>sample size</dd>

</dl>

sdY.est: Estimate trait variance, internal function

Description

Usage

Value

Arguments

Author

Details