GnomADgenes

This dataframe contains variants from the GnomAD database with MAF values in the Non-Finnish European (NFE)
 and their consequences from VEP with each associated gene in build version 37.

Rare variant association tests: burden tests (Bocher et al. 2019 <doi:10.1002/gepi.22210>) and the Sequence Kernel Association Test (Bocher et al. 2021 <doi:10.1038/s41431-020-00792-8>) in the whole genome; and genetic simulations.

Ozvan Bocher

Ravages

Rare Variant Analysis and Genetic Simulations

GnomADgenes function

GnomADgenes is a dataframe with five columns:<dl>
 <dt>chr</dt>
<dd>The chromosome of the variant</dd> <dt>pos</dt>
<dd>The position of the variant</dd> <dt>consequence</dt>
<dd>The functionnal consequence of the variant predicted by Variant Effect Predictor (VEP)</dd> <dt>gene</dt>
<dd>The gene associated to each variant predicted by VEP</dd> <dt>maf</dt>
<dd>The MAF of the variant in the NFE population</dd> 
</dl>

Format

GnomADgenes dataset — GnomADgenes

GnomADgenes is a dataframe with five columns:<dl>
 <dt>chr</dt>
<dd>The chromosome of the variant</dd>

 <dt>pos</dt>
<dd>The position of the variant</dd>

 <dt>consequence</dt>
<dd>The functionnal consequence of the variant predicted by Variant Effect Predictor (VEP)</dd>

 <dt>gene</dt>
<dd>The gene associated to each variant predicted by VEP</dd>

 <dt>maf</dt>
<dd>The MAF of the variant in the NFE population</dd>

 
</dl>

GnomADgenes: GnomADgenes dataset

Description

Usage

Arguments

Format