ReAD (version 1.0.1)

SimuData: Simulate two sequences of p-values by accounting for the local dependence structure via a hidden Markov model.

Description

Simulate two sequences of p-values by accounting for the local dependence structure via a hidden Markov model.

Usage

SimuData(
  J = 10000,
  pi = c(0.25, 0.25, 0.25, 0.25),
  A = 0.6 * diag(4) + 0.1,
  muA = 2,
  muB = 2,
  sdA = 1,
  sdB = 1
)

Value

A list:

pa

A numeric vector of p-values from study 1.

pb

A numeric vector of p-values from study 2.

theta1

The true states of features in study 1.

theta2

The true states of features in study 2.

Arguments

J

The number of features to be tested in two studies.

pi

The stationary probabilities of four hidden joint states.

A

The 4-by-4 transition matrix.

muA

Mean of the normal distribution generating the p-value in study 1.

muB

Mean of the normal distribution generating the p-value in study 2.

sdA

The standard deviation of the normal distribution generating the p-value in study 1.

sdB

The standard deviation of the normal distribution generating the p-value in study 2.