EWAS using Reference-Free DNA Methylation Mixture Deconvolution
Description
Reference-free method for conducting EWAS while deconvoluting DNA methylation
arising as mixtures of cell types. The older method
(Houseman et al., 2014,) is similar to
surrogate variable analysis (SVA and ISVA), except that it makes additional use
of a biological mixture assumption.
The newer method (Houseman et al., 2016, ) is similar
to non-negative matrix factorization, with additional constraints
and additional utilities.