RepeatedHighDim (version 2.3.0)

GlobTestMissing: Detection of global group effect

Description

Detection of global group effect

Usage

GlobTestMissing(X1, X2, nperm = 100)

Value

The p-value of a permutation test.

Arguments

X1

Matrix of expression levels in first group. Rows represent features, columns represent samples.

X2

Matrix of expression levels in second group. Rows represent features, columns represent samples.

nperm

Number of permutations.

Author

Klaus Jung

Details

Tests a global effect for a set of molecular features (e.g. genes, proteins,...) between the two groups of samples. Missing values are allowd in the expression data. Samples of the two groups are supposed to be unpaired.

References

Jung K, Dihazi H, Bibi A, Dihazi GH and Beissbarth T (2014): Adaption of the Global Test Idea to Proteomics Data with Missing Values. Bioinformatics, 30, 1424-30. tools:::Rd_expr_doi("10.1093/bioinformatics/btu062")

See Also

For more information, please refer to the package's documentation and the tutorial: https://software.klausjung-lab.de/.

Examples

### Global comparison of a set of 100 proteins between two experimental groups,
### where (tau * 100) percent of expression levels are missing.
n1 = 10
n2 = 10
d = 100
tau = 0.1
X1 = t(matrix(rnorm(n1*d, 0, 1), n1, d))
X2 = t(matrix(rnorm(n2*d, 0.1, 1), n2, d))
X1[sample(1:(n1*d), tau * (n1*d))] = NA
X2[sample(1:(n2*d), tau * (n2*d))] = NA
GlobTestMissing(X1, X2, nperm=100)