Roleswitch (version 1.10.0)
Infer miRNA-mRNA interactions using paired expression data from
a single sample
Description
Infer Probabilities of MiRNA-mRNA Interaction Signature
(ProMISe) using paired expression data from a single sample.
Roleswitch operates in two phases by inferring the probability
of mRNA (miRNA) being the targets ("targets") of miRNA (mRNA),
taking into account the expression of all of the mRNAs (miRNAs)
due to their potential competition for the same miRNA (mRNA).
Due to dynamic miRNA repression in the cell, Roleswitch assumes
that the total transcribed mRNA levels are higher than the
observed (equilibrium) mRNA levels and iteratively updates the
total transcription of each mRNA targets based on the above
inference. NB: in the paper, we used ProMISe as both the model
name and inferred score name.