Rsmlx (version 2023.1.5)

pkpopini: Compute initial population PK parameters

Description

Use the pooled PK data to derive population PK parameters for a "standard" PK model (i.e. a model of the Monolix PK library). The structural model is automatically defined using the names of the PK parameters. Allowed names are: 'Tlag', 'Mtt', 'Ktr', 'ka', 'Tk0', 'V', 'V1', 'V2', 'V3', 'Q', 'Q2', 'Q3', 'Cl', 'k', 'k12', 'k21', 'k13', 'k31', 'Vm', 'Km'.

Usage

pkpopini(
  data = NULL,
  project = NULL,
  parameter = NULL,
  new.project = NULL,
  new.dir = NULL,
  par.ini = NULL
)

Value

A list of results

Arguments

data

a list with fields

• dataFile: path to a formatted data file

• headerTypes: a vector of strings

project

a Monolix project

parameter

a vector of strings (names of the PK parameters)

new.project

name of the new Monolix project (a default name is created if not provided)

new.dir

name of the directory where the created files are stored (default is the current working directory) )

par.ini

a vector of PK parameter values

Details

A Monolix project is then automatically created using these values as initial population parameters.

See https://monolix.lixoft.com/rsmlx/pkpopini/ for more details.

Examples

if (FALSE) {
# Create in the working directory a Monolix project for a 1 cpt model with 
# lag time, 0 order absorption and linear elimination
warf.ini1 <- pkpopini(data=warfarin, param=c("Tlag", "Tk0", "V", "Cl")) 

# Create in directory 'warfarin' a Monolix project called 'warfPK2.mlxtran' 
# for a 2 cpt model with 1st order absorption and nonlinear elimination
warf.ini3 <- pkpopini(data=warfarin, param=c("ka", "V", "k12", "k21", "Vm", "Km"), 
                      new.dir="warfarin", new.project="warfPK2.mlxtran") 
}