RefTMB

<p>The pan-cancer repertoire of reference signatures and 
  the reference TMB (Tumor mutation burden) signature profiles 
  of SBS (Single base substitutions) and
  DBS (Double base substitutions).</p>

data

Performs mutational signature analysis for targeted sequenced tumors. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation counts matrix into a panel context matrix (measuring the size of the targeted sequenced genome for each tumor in the unit of million base pairs (Mb)), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed by a signature, namely signature burden, for each targeted sequenced tumor. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>.

RefTMB: Example Data

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