Simulated data as an example
This file consists of the list SimData with the following objects:
V : Simulated mutation catalog matrix of size 96 by 10027 generated from the Poisson distribution with the mean corresponding to each element of L*(WH), where * is elementwise multiplication, L is the panel size matrix below, W is the profile matrix of the tumor mutation burden (TrueW_TMB below), and H is the signature activity matrix (TrueH below).
L : Panel size matrix of size 96 by 10027.
TrueH : Simulated signature activity matrix of size 6 by 10027 used to generate V.
TrueW_TMB : Tumor mutation burden based signatures size 96 by 6 for 6 SBS signatures (SBS1, SBS2/13, SBS4, SBS5, SBS40, SBS89) used to generate V.
SingleTumorEx : A single simulated tumor (column singleV)
and its sequencing context (column singleL).
PanelEx: An example sequencing panel information with Chromosome, Start_Position, End_Position, SEQ_ASSAY_ID.
PatientInfo: An example patient data containing patients ID associated with SEQ_ASSAY_ID.