In the paper describing methodological aspects of our algorithm we present the analysis of information transmission in NfkB pathway upon the stimulation of TNF-\(\alpha\). Experimental data from this experiment in the form of single-cell time series are attached to the package as a data.frame object and can be accessed using `data_nfkb` variable. Each row of `data_nfkb` represents a single observation of a cell. Column 'signal' indicates the level of TNF-\(\alpha\) stimulation for a given cell, while columns 'response_T', gives the normalised ratio of nuclear and cytoplasmic transcription factor as described in Supplementary Methods of the corresponding publication. In the CRAN version of the package we included only a subset of the data (5 time measurements). For the full datasets, please access GitHub pages.
data_nfkbA data frame with 15632 rows and 6 variables:
Level of TNFa stimulation
The concentration of normalised NfkB transcription factor, measured at time 0
The concentration of normalised NfkB transcription factor, measured at time 3
The concentration of normalised NfkB transcription factor, measured at time 21
The concentration of normalised NfkB transcription factor, measured at time 90
The concentration of normalised NfkB transcription factor, measured at time 120
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For each concentration, there are at least 1000 single-cell observation (with the exception of 0.5ng stimulation, where the number of identified cells is almost 900)