SLGI (version 1.32.0)

normInteraction: Normalize a matrix of biological interactions

Description

Normalize a square matrix of biological interactions according to the number of possible interactions between each biological complex.

Usage

normInteraction(data, genename, interactome)

Arguments

data

Square Matrix of biological complexes that shares one or more genes(proteins)

genename

Character vector of the gene names that possibly create interactions between complexes

interactome

Adjacency matrix where row are genes and columns are cellular organizational units. Each entry has value 0 or 1, for absence or presence of a gene in a complex, e.g., ScISI

Value

Square matrix of biological complexes linked by one or more interacting proteins and normalized by the possible number of interactions between each complex.

See Also

getInteraction

Examples

data(Atong)
data(ScISIC)
data(SGA)
SLa2 <- gi2Interactome(Atong, ScISIC)
## Search for synthetic lethal interaction
compM <- getInteraction(SLa2, SGA, ScISIC)
## Normalize
normIntComplex<- normInteraction(compM$bwMat, SGA, ScISIC)