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SNPassoc (version 1.6-0)

SNPs-based whole genome association studies

Description

This package carries out most common analysis when performing whole genome association studies. These analyses include descriptive statistics and exploratory analysis of missing values, calculation of Hardy-Weinberg equilibrium, analysis of association based on generalized linear models (either for quantitative or binary traits), and analysis of multiple SNPs (haplotype and epistasis analysis). Permutation test and related tests (sum statistic and truncated product) are also implemented.

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Version

Install

install.packages('SNPassoc')

Monthly Downloads

1,476

Version

1.6-0

License

GPL (>= 2)

Maintainer

Juan Gonzalez

Last Published

July 18th, 2009

Functions in SNPassoc (1.6-0)

HapMap

SNPs from HapMap project
intervals

Print ORs and 95% confidence intervals for an object of class 'haplo.glm'
GenomicControl

Population substructure
scanWGassociation

Whole genome association analysis
snp

SNP object
sortSNPs

Sort a vector of SNPs by genomic position
make.geno

Create a group of locus objects from some SNPs, assign to 'model.matrix' class.
odds

Extract odds ratios, 95% CI and pvalues
tableHWE

Test for Hardy-Weinberg Equilibrium
plot.WGassociation

Function to plot -log p values from an object of class 'WGassociation'
inheritance

Collapsing (or recoding) genotypes into different categories (generally two) depending on a given genetic mode of inheritance
SNPs

SNPs in a case-control study
Table.N.Per

Descriptive sample size and percentage
qqpval

Functions for inspecting population substructure
Table.mean.se

Descriptive sample size, mean, and standard error
Bonferroni.sig

Bonferroni correction of p values
LD

max-statistic for a 2x3 table
int

Identify interaction term
setupSNP

Convert columns in a dataframe to class 'snp'
plotMissing

Plot of missing genotypes
permTest

Permutation test analysis
is.Monomorphic

Check whether a SNP is Monomorphic
interactionPval

Two-dimensional SNP analysis for association studies
WGassociation

Whole genome association analysis
getSignificantSNPs

Extract significant SNPs from an object of class 'WGassociation'
association

Association analysis between a single SNP and a given phenotype
haplo.interaction

Haplotype interaction with a covariate
SNPassoc-internal

Internal SNPstat functions
maxstat

max-statistic for a 2x3 table