SPCDAnalyze (version 0.1.0)

placeboNonResponder: Example of helper function for determining placebo nonresponse

Description

The input to SPCDcontinuous requires a logical field which says that the patient was not a placebo responder in the the first phase of the study. Usually this is determined by whether their outcome was greater than a specified value but could have other criteria. This an example program which specifies non-responders as patients whose first phase results were greater than a constant.

Usage

placeboNonResponder(data, ID = "ID", k = 0)

Arguments

data

The data file to use to determine non-response.

ID

Text field indicating the name of the Patient ID variable.

k

A numeric constant. A patient is a non-responder if their change from baseline was greater than k.

Value

A new data frame with a variable named nonResponder.

References

Chen, Y. F., Yang, Y., Hung, H. J., & Wang, S. J. (2011). Evaluation of performance of some enrichment designs dealing with high placebo response in psychiatric clinical trials. Contemporary clinical trials, 32,4, 592-604.

Examples

# NOT RUN {
data1=createTestData(times=0:11,n=c(50,50,50),transition=5,rx1=0,rx2=0)
data1=placeboNonResponder(data1,k=0)
# }