SPINA (version 4.1.0)

SPINA.GD: Calculated Sum Activity of Step-Up Deiodinases (SPINA-GD)

Description

Calculate total step-up deiodinase activity (SPINA-GD) from equilibrium free hormone concentrations. This is an alias for estimated.GD.

Usage

SPINA.GD(FT4, FT3)

Arguments

FT4

Free thyroxine (FT4) concentration in pmol/L.

FT3

Free triiodothyronine (FT3) concentation in pmol/L

Value

This function returns step-up deiodinase activity as a numeric result representing a single value or a vector, depending on the vector length of the arguments. Results are in nmol/s.

Details

This function is able to do vectorised calculations.

References

Dietrich J. W., Landgrafe G., Fotiadou E. H. 2012 TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. PMID: 23365787; PMCID: PMC3544290.

Dietrich J. W., Landgrafe-Mende G., Wiora E., Chatzitomaris A., Klein H. H., Midgley J. E., Hoermann R. 2016 Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.

See Also

SPINA.GD, estimated.GT, SPINA.GT, estimated.GDTT, SPINA.GDTT, estimated.GTT, SPINA.GTT, estimated.sGD, SPINA.sGD, estimated.TSHI, estimated.sTSHI, estimated.TTSI,

Examples

# NOT RUN {
TSH <- c(1, 3.24, 0.7);
FT4 <- c(16.5, 7.7, 9);
FT3 <- c(4.5, 28, 6.2);
print(paste("GT^:", SPINA.GT(TSH, FT4)));
print(paste("GD^:", SPINA.GD(FT4, FT3)));
print(paste("sGD^:", SPINA.sGD(FT4, FT3)));
# }