Calibrate the design parameters for the Single-to-double Arm Transition Design
Usage
findparameter(p0,p1,alpha1,beta1,alpha2,beta2)
Arguments
p0
The minimally required level for the response rate to be clinically meaningful.
p1
The desirable target rate.
alpha1
The type I error rate in the first stage.
beta1
The type II error rate in the first stage.
alpha2
The type I error rate in the second stage.
beta2
The type II error rate in the second stage.
Value
n1
The number of subjects in the experimental arm in the single-arm stage.
n2
The number of subjects in each arm in the double-arm stage.
r1
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.The number of responses observed at the end of single-arm stage should be greater than or equal to \(r1\) for the trial to proceed.
ess0
The expected sample size under the null hypothesis.
ess1
The expected sample size under the alternative hypothesis.
asn
The average sample number taken as the average of \(ess0\) and \(ess1\).
References
Shi H., Yin G. (2017), START: Single-to-double Arm Transition Design for Phase II Clinical Trials. Submitted.