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SeqFeatR (version 0.3.1)

A Tool to Associate FASTA Sequences and Features

Description

Provides user friendly methods for the identification of sequence patterns that are statistically significantly associated with a property of the sequence. For instance, SeqFeatR allows to identify viral immune escape mutations for hosts of given HLA types. The underlying statistical method is Fisher's exact test, with appropriate corrections for multiple testing, or Bayes. Patterns may be point mutations or n-tuple of mutations. SeqFeatR offers several ways to visualize the results of the statistical analyses, see Budeus (2016) .

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Version

Install

install.packages('SeqFeatR')

Monthly Downloads

223

Version

0.3.1

License

GPL (>= 3)

Maintainer

Bettina Budeus

Last Published

April 12th, 2019

Functions in SeqFeatR (0.3.1)

assocpointpair

Compare results of SeqFeatRs assocpoint with SeqFeatRs assocpair, assocpairfeat
rewritetuple

Rewrite result from SeqFeatRs assoctuple
smallmanhattan

A small version of manhattan plot
orPlot

Visualize odds ratios and p-values from SeqFeatRs assocpoint
q-values

Calculate q-values from p-values
volcanoplot

Create volcano plot
visualizepairfeat

Visualize pairs of sequence alignment positions associated with sequence feature.
tartan

Visualize association of mutation pairs and features from two (comparable) analyses.
visualizepair

Visualize pairs of alignment positions that jointly mutate
assoctuple

Searches for associations of a tuple of alignment positions with feature(s)
comparewithancestral

Compares ancestral sequence with sequence alignment
assocpointhierarchical

Searches for associations of single alignment positions with feature(s) with a simple hierarchical model
assocpairfeat

Finding pairs of sequence alignment positions associated with sequence feature.
assocpoint

Searches for associations of single alignment positions with feature(s)
SeqFeatRGUI

GUI for SeqFeatR
assocpair

Finding pairs of alignment positions that jointly mutate
foundereffectfinder

Tries to identify a founder effect in results from SeqFeatRs assocpair
getfreqs

Get frequencies for amino acids/nucleotides in alignment window (epitope)