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Sequential (version 4.5.1)

Exact Sequential Analysis for Poisson and Binomial Data

Description

Functions to calculate exact critical values, statistical power, expected time to signal, and required sample sizes for performing exact sequential analysis. All these calculations can be done for either Poisson or binomial data, for continuous or group sequential analyses, and for different types of rejection boundaries. In case of group sequential analyses, the group sizes do not have to be specified in advance and the alpha spending can be arbitrarily settled. For regression versions of the methods, Monte Carlo and asymptotic methods are used.

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Version

Install

install.packages('Sequential')

Monthly Downloads

1,573

Version

4.5.1

License

GPL-2

Maintainer

Ivair Silva

Last Published

October 29th, 2025

Functions in Sequential (4.5.1)

AnalyzeRegression.CondPoisson

Function for MaxSPRT regression analyses with conditional Poisson data, without the need to know group sizes a priori.
Analyze.CondPoisson

Function to conduct group sequential analyses for conditional Poisson data without the need to know group sizes a priori.
Analyze.Binomial

Function for group sequential analyses for binomial data, without the need to know group sizes a priori.
AnalyzeRegression.Poisson

Function for MaxSPRT regression analyses with Poisson data, without the need to know group sizes a priori.
AnalyzeSetUp.Binomial

Function to set up input parameters before using the Analyze.Binomial function for the first time.
AnalyzeSetUp.CondPoisson

Function to set up input parameters before using the Analyze.CondPoisson function for the first time.
Analyze.wBinomial

Function for group sequential analyses of multiple weighted binomial endpoints, without the need to know group sizes a priori.
Analyze.Multinomial

Function for group sequential analyses for multinomial data, without the need to know group sizes a priori.
AnalyzeRegression.Binomial

Function for MaxSPRT regression analyses with binary/binomial data, without the need to know group sizes a priori.
Analyze.Poisson

Function to conduct group sequential analyses for Poisson data without the need to know group sizes a priori.
CV.Binomial

Calculates exact critical values for group and continuous sequential analysis with binomial data.
AnalyzeSetUpRegression.Poisson

Function to set up input parameters before using the AnalyzeRegression.Poisson function for the first time.
AnalyzeSetUp.Poisson

Function to set up input parameters before using the Analyze.Poisson function for the first time.
AnalyzeSetUpRegression.Binomial

Function to set up input parameters before using the AnalyzeRegression.Binomial function for the first time.
AnalyzeSetUp.wBinomial

Function to set up input parameters before using the Analyze.wBinomial function for the first time.
AnalyzeSetUpRegression.CondPoisson

Function to set up input parameters before using the AnalyzeRegression.CondPoisson function for the first time.
AnalyzeSetUp.Multinomial

Function to set up input parameters before using the Analyze.Multinomial function for the first time.
CV.Poisson

Critical values for group and continuous sequential analysis with Poisson data.
ConfidenceInterval.Binomial

Confidence Interval for the Relative Risk Following a Sequential Test with Binary Data.
CV.CondPoisson

Critical values for continuous sequential CMaxSPRT for Poisson data with limited information from historical cohort.
Performance.Threshold.CondPoisson

Performance and alpha spending for user-defined signaling threshold for sequential analysis with conditional Poisson data.
Performance.Binomial

Statistical power, expected time to signal and expected sample size for group and continuous sequential analysis with binomial data.
Performance.Poisson

Calculates statistical power, expected time to signal and expected sample size for group and continuous sequential analysis with Poisson data.
Performance.AlphaSpend.Binomial

Calculates performance and signaling threshold for user-defined alpha spending for sequential analysis with binomial data.
Optimal.Binomial

Optimal alpha spending for minimizing expected time to signal for continuous and group sequential analysis with binomial data.
Performance.Threshold.Binomial

Statistical Performance and Alpha Spending For User-defined Signaling Threshold With Binomial Data.
Performance.AlphaSpend.Poisson

Calculates performance and signaling thresholds for user-defined alpha spending for sequential analysis with Poisson data.
Performance.CondPoisson

Statistical power, expected time to signal and expected sample size for the continuous sequential CMaxSPRT for Poisson data with limited information from historical cohort.
Performance.Threshold.Poisson

Performance and alpha spending for user-defined signaling threshold for sequential analysis with Poisson data.
Performance.AlphaSpend.CondPoisson

Calculates performance and signaling thresholds for user-defined alpha spending for sequential analysis with conditional Poisson data.
SampleSize.Poisson

Sample size calculation for continuous sequential analysis with Poisson data.
SampleSize.Binomial

Sample size calculation for continuous sequential analysis with binomial data.
SampleSize.CondPoisson

Sample size calculation for the continuous sequential CMaxSPRT for Poisson data with limited information from historical cohort.
Sequential-package

Analysis Support, Critical Values, Power, Time to Signal and Sample Size for Sequential Analysis with Poisson and Binomial Data.