example_data

<p>(Artificial) Concentration data for 2 formulas, each including 12 tablets.
Concentrations are measured at six points in time.</p>

datasets

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) <doi:10.1002/sim.7689> for details.

Kathrin Moellenhoff

SimDissolution

Modeling and Assessing Similarity of Drug Dissolutions Profiles

example_data function

<p>A data frame with 24 rows and 8 variables including tablet, group and measurements at six points in time.</p>

example_data: Time-Concentration data for two formulas

Description

Usage

Arguments

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