SimEvolEnzCons (version 2.0.0)

coef_rep: Response coefficient computation

Description

Computes the response coefficients for each enzyme

Usage

coef_rep(E_fun,A_fun,correl_fun,beta_fun=NULL)

Arguments

E_fun

Numeric vector of concentrations

A_fun

Numeric vector of activities

correl_fun

Character string indicating the abbreviation of the constraint applied on the system

beta_fun

Matrix of co-regulation coefficients

Value

Numeric vector of the response coefficients of each enzyme

Details

The response coefficients are influenced by the applied constraint.

Response coefficients are an extension of the control coefficients defined in the Metabolic Control Theory (Kacser and Burns, 1973). For further details on how the response coefficient is calculated, see Lion et al. (2004).

A_fun and E_fun need to have the same length. The restrictions on beta_fun are explained in alpha_ij.

References

Lion, S., F. Gabriel, B. Bost, J. Fi<U+00E9>vet, C. Dillmann, and D. De Vienne, 2004. An extension to the metabolic control theory taking into account correlations between enzyme concentrations. European Journal of Biochemistry 271:4375<U+2013>4391.

See Also

Use function activities to compute enzyme activities.

Examples

# NOT RUN {
A <- c(1,10,30)
E <- c(30,30,30)
beta <- matrix(c(1,10,5,0.1,1,0.5,0.2,2,1),nrow=3)
correl <- "SC"

response <- coef_rep(E,A,correl,beta)


# result : response = c(0.88235294, 0.08823529, 0.02941176)

# }