Create new seed founder for pedigree.
create_founder(FamID, GRR, carrier_prob, RVfounder, founder_byears)
Numeric. The family ID to assign to the simulated pedigree.
Numeric. The genetic relative-risk of disease, i.e. the relative-risk of disease for individuals who carry at least one copy of the causal variant. Note: When simulating diseases with multiple subtypes GRR
must contain one entry for each simulated subtype. See details.
Numeric. The carrier probability for all causal variants with relative-risk of disease GRR
. By default, carrier_prob
= 0.002
Logical. Indicates if all pedigrees segregate the rare, causal variant. By default, RVfounder = FALSE
See details.
Numeric vector of length 2. The span of years from which to simulate, uniformly, the birth year for the founder who introduced the rare variant to the pedigree.
new_founder_info
the pedigree information for the new mate.