Determine founder genotype at the disease locus and determime their relative-risk of disease
sim_founderRVstatus(GRR, carrier_prob, RVfounder)Numeric. The genetic relative-risk of disease, i.e. the relative-risk of disease for individuals who carry at least one copy of the causal variant. Note: When simulating diseases with multiple subtypes GRR must contain one entry for each simulated subtype. See details.
Numeric. The carrier probability for all causal variants with relative-risk of disease GRR. By default, carrier_prob = 0.002
Logical. Indicates if all pedigrees segregate the rare, causal variant. By default, RVfounder = FALSE See details.
Logical. If intro_RV = TRUE a founder has introduced a rare, causal variant to the pedigree, otherwise no RV has been introduced to the pedigree.
A list containing: 1. the founder's genotype at the disease locus, their relative-risk of disease, and an updated value for intro_RV.