Sleuth2 (version 1.0-3)

case0501: Diet Restriction and Longevity

Description

Female mice were randomly assigned to six treatment groups to investigate whether restricting dietary intake increases life expectancy. Diet treatments were:

1. "NP"---mice ate unlimited amount of nonpurified, standard diet
2. "N/N85"---mice fed normally before and after weaning. After weaning, ration was controlled at 85 kcal/wk
3. "N/R50"---normal diet before weaning and reduced calorie diet (50 kcal/wk) after weaning
4. "R/R50"---reduced calorie diet of 50 kcal/wk both before and after weaning
5. "N/R50 lopro"---normal diet before weaning, restricted diet (50 kcal/wk) after weaning and dietary protein content decreased with advancing age
6. "N/R40"---normal diet before weaning and reduced diet (40 Kcal/wk) after weaning.

Usage

case0501

source

Ramsey, F.L. and Schafer, D.W. (2002). The Statistical Sleuth: A Course in Methods of Data Analysis (2nd ed), Duxbury.

References

Weindruch, R., Walford, R.L., Fligiel, S. and Guthrie D. (1986). The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake, Journal of Nutrition 116(4):641--54.

Examples

str(case0501)
boxplot(Lifetime~Diet, width=c(rep(.8,6)), data=case0501,
        xlab="Diet", ylab="Lifetime in months")
summary(subset(case0501, Diet=="NP", Lifetime))