Sleuth2 (version 2.0-7)

case1602: Oat Bran and Cholesterol

Description

In a randomized, double-blind, crossover experiment, researchers randomly assigned 20 volunteer hospital employees to either a low-fiber or low-fiber treatment group. The subjects followed the diets for six weeks. After two weeks on their normal diet, all patients crossed over to the other treatment group for another six weeks. The total serum cholesterol (in mg/dl) was measured on each patient before the first treatment, at the end of the first six week treatment, and at the end of the second six week treatment.

Usage

case1602

Format

A data frame with 20 observations on the following 4 variables.

Baseline

total serum cholesterol before treatment

Hifiber

total serum cholesterol after the high fiber diet

Lofiber

total serum cholesterol after the low fiber diet

Order

factor to identify order of treatment, with two levels "HL" and "LH"

References

Swain, J.F., Rouse, I.L., Curley, C.B., and Sacks, F.M. (1990). Comparison of the Effects of Oat Bran and Low-fiber Wheat on Serum Lipoprotein Levels and Blood Pressure, New England Journal of Medicine 320: 1746--1747.

Examples

str(case1602)

subjects <- 1:20
ordersubjects <- order(case1602$Baseline)
plot(1:20, case1602$Baseline[ordersubjects], pch=24,
     xlab="Subjects (Ordered According to Baseline Cholesterol)",
     ylab="Total Serum Cholesterol (mg/dl)")
points(1:20, case1602$Lofiber[ordersubjects], pch=19, col=5)
points(1:20, case1602$Hifiber[ordersubjects], pch=21, col=3)
legend(1,245,legend=c("Baseline","After Low Fiber Diet","After High Fiber Diet"),
  pch=c(24,19,21),col=c(1,5,3))

diff <- with(case1602, Hifiber-Lofiber)
plot(subjects, diff, pch=ifelse(case1602$Order=="HL",19,21))
abline(h=0)
t.test(diff ~ Order, case1602) # Test for order of treatment effect
t.test(diff) # Test for treatment effect