Drug interaction study with oral contraceptives
A data frame with 44 observations on the following 6 variables.
IDID number for each of the women
StudyPeriod1=first or 2=second
TreatmentDrug or Placebo
EEBioavailability of the ethinyl estradiol component of the oral contraceptive (in pg*hr/ml)
ComparisonValuesComparison values used for a Tukey nonadditivity plot
ResidualsResiduals used for a Tukey nonadditivity plot
Twenty-two female subjects were allocated randomly to one of two treatment sequences in a two period crossover design. The two treatments were a new Drug D or placebo, both given concomitantly with a standard oral contraceptive which was given in both study periods. The oral contraceptive has two components, ethinyl estradiol (EE) and norethindrone (NET). The purpose of the study was to evaluate whether the presence of Drug D affected the bioavailability of each of the oral contraceptive components. Note that our dataset does not include the NET variable.