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SubTite (version 4.0.5)

Subgroup Specific Optimal Dose Assignment

Description

Chooses subgroup specific optimal doses in a phase I dose finding clinical trial allowing for subgroup combination and simulates clinical trials under the subgroup specific time to event continual reassessment method. Chapple, A.G., Thall, P.F. (2018) .

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Version

Install

install.packages('SubTite')

Monthly Downloads

168

Version

4.0.5

License

GPL-2

Maintainer

Andrew Chapple

Last Published

September 15th, 2021

Functions in SubTite (4.0.5)

MCMCSIM

Performs MCMC and returns needed values for dose-finding in a list.
GetParams

Obtains true simulation parameters for each supported distribution function to correspond to a probability of the truth by time T1.
GetSubTite

Gives the subgroup specific optimal dose vector.
Print_SubTite

Gives summaries of GetSubTite Objects.
GetESS

Determines Prior ESS for fixed values of sigma_alpha^2 and sigmabeta^2
GetPriorMeans

Calibrates prior means for Dose Finding Trial
SimTrial

Simulates a Sub-TITE trial design
SimTrial1

Simulates a Sub-TITE trial design
MCMC

Performs MCMC and returns needed values for dose-finding in a list.