Subtype_drugs

The result data of the simulation is generated by the functional OCSSD.

datasets

A systematic biology tool was developed to prioritize cancer subtype-specific drugs by integrating genetic perturbation, drug action, biological pathway, and cancer subtype.
The capabilities of this tool include inferring patient-specific subpathway activity profiles in the context of gene expression profiles with subtype labels, calculating differentially
expressed subpathways based on cultured human cells treated with drugs in the 'cMap' (connectivity map) database, prioritizing cancer subtype specific drugs according to drug-disease
reverse association score based on subpathway, and visualization of results (Castelo (2013) <doi:10.1186/1471-2105-14-7>; Han et al (2019) <doi:10.1093/bioinformatics/btz894>; Lamb and Justin (2006) <doi:10.1126/science.1132939>). Please cite using <doi:10.1093/bioinformatics/btab011>.

Junwei Han

SubtypeDrug

Prioritization of Candidate Cancer Subtype Specific Drugs

Subtype_drugs function

A list containing 8 variables.
The variables are as follows:<ul>
<li>Basal Results table for basal subtype</li>
<li>Her2 Results table for Her2 subtype</li>
<li>LumA Results table for LumA subtype</li>
<li>LumB Results table for LumB subtype</li>
<li>DrugMatrix Drug disease reverse association matrix</li>
<li>SubpathwayMatrix Subpathway activity natrix</li>
<li>SampleInformation Cancer sample phenotypic information</li>
<li>Parameter Parameter of the function OCSSD</li>
</ul>

Subtype_drugs: Simulation result data

Description

Usage

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Examples