constructor_ICA_estimator

The <code>constructor_ICA_estimator()</code> function returns a function the estimates
the ICA as a user-specified function of \(I(\Delta S; \Delta T)\),
\(\Delta S\), and \(\Delta T\).

In a clinical trial, it frequently occurs that the most credible
outcome to evaluate the effectiveness of a new therapy (the true endpoint) is
difficult to measure. In such a situation, it can be an effective strategy to
replace the true endpoint by a (bio)marker that is easier to measure and that
allows for a prediction of the treatment effect on the true endpoint (a
surrogate endpoint). The package 'Surrogate' allows for an evaluation of the
appropriateness of a candidate surrogate endpoint based on the meta-analytic,
information-theoretic, and causal-inference frameworks. Part of this software
has been developed using funding provided from the European Union's Seventh
Framework Programme for research, technological development and demonstration
(Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt
University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland
Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine.

Wim der Elst

Surrogate

Evaluation of Surrogate Endpoints in Clinical Trials

Wim Van Der Elst

Florian Stijven

Fenny Ong

Dries De Witte

Gokce Deliorman

Paul Meyvisch

Alvaro Poveda

Ariel Alonso

Hannah Ensor

Christoper Weir

Geert Molenberghs

constructor_ICA_estimator function

<dl><dt>endpoint_types</dt>
<dd>(character) vector with two elements indicating the
endpoint types: <code>"continuous"</code> or <code>"ordinal"</code>.</dd>
<dt>ICA_def</dt>
<dd>function that takes the following arguments: \(I(\Delta S;
 \Delta T)\), \(\Delta S\), and \(\Delta T\). It returns the ICA as a
function of these information-theoretic quantities.</dd></dl>

Arguments

Function constructor to estimate the ICA given a set of sampled patient-level
treatment effects — constructor_ICA_estimator

<dl>

<dt>endpoint_types</dt>
<dd>(character) vector with two elements indicating the
endpoint types: <code>"continuous"</code> or <code>"ordinal"</code>.</dd>


<dt>ICA_def</dt>
<dd>function that takes the following arguments: \(I(\Delta S;
 \Delta T)\), \(\Delta S\), and \(\Delta T\). It returns the ICA as a
function of these information-theoretic quantities.</dd>

</dl>

Function constructor to estimate the ICA given a set of sampled patient-level
treatment effects

constructor_ICA_estimator: Function constructor to estimate the ICA given a set of sampled patient-level treatment effects

Description

Usage

Value

Arguments