example.data

Provides functions to implement group sequential procedures that allow for early stopping to declare efficacy using a surrogate marker and the possibility of futility stopping. More details are available in: Parast, L. and Bartroff, J (2024) <doi:10.1093/biomtc/ujae108>. A tutorial for this package can be found at <https://www.laylaparast.com/surrogateseq>. A Shiny App implementing the methods can be found at <https://parastlab.shinyapps.io/SurrogateSeqApp/>.

Layla Parast

SurrogateSeq

Group Sequential Testing of a Treatment Effect Using a Surrogate
Marker

Jay Bartroff

example.data function

A list with 9 elements:<dl>
 	 <dt><code>w0.p</code></dt>
<dd>the baseline covariate in the control group in the prior study (Study A)</dd> <dt><code>s0.p</code></dt>
<dd>the surrogate marker in the control group in the prior study (Study A</dd> <dt><code>y0.p</code></dt>
<dd>the primary outcome in the control group in the prior study (Study A</dd> 	 <dt><code>w1</code></dt>
<dd>a baseline covariate in the treatment group in the current study (Study B)</dd> <dt><code>w0</code></dt>
<dd>a baseline covariate in the control group in the current study (Study B)</dd> <dt><code>s1</code></dt>
<dd>the surrogate marker in the treatment group in the current study (Study B)</dd> <dt><code>s0</code></dt>
<dd>the surrogate marker in the control group in the current study (Study B)</dd> <dt><code>y1</code></dt>
<dd>the primary outcome in the treatment group in the current study (Study B)</dd> <dt><code>y0</code></dt>
<dd>the primary outcome in the control group in the current study (Study B)</dd>
</dl>

Format

Example data — example.data

A list with 9 elements:<dl>
 	 <dt><code>w0.p</code></dt>
<dd>the baseline covariate in the control group in the prior study (Study A)</dd>

 <dt><code>s0.p</code></dt>
<dd>the surrogate marker in the control group in the prior study (Study A</dd>

 <dt><code>y0.p</code></dt>
<dd>the primary outcome in the control group in the prior study (Study A</dd>

 	 <dt><code>w1</code></dt>
<dd>a baseline covariate in the treatment group in the current study (Study B)</dd>

 <dt><code>w0</code></dt>
<dd>a baseline covariate in the control group in the current study (Study B)</dd>

 <dt><code>s1</code></dt>
<dd>the surrogate marker in the treatment group in the current study (Study B)</dd>

 <dt><code>s0</code></dt>
<dd>the surrogate marker in the control group in the current study (Study B)</dd>

 <dt><code>y1</code></dt>
<dd>the primary outcome in the treatment group in the current study (Study B)</dd>

 <dt><code>y0</code></dt>
<dd>the primary outcome in the control group in the current study (Study B)</dd>


</dl>

example.data: Example data

Description

Usage

Arguments

Format

Examples