SynergyLMM (version 1.1.2)
Statistical Framework for in Vivo Drug Combination Studies
Description
A framework for evaluating drug combination effects in preclinical in vivo studies.
'SynergyLMM' provides functions to analyze longitudinal tumor growth experiments using mixed-effects models,
perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance,
and assess both post-hoc and a priori statistical power.
The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, ).
The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, ),
and Gałecki and Burzykowski (2013, ).