teqr.MTDdataconACT

includes the simulation results data, cohortSize,proba,probc, MTDss,pTarget,lowerlimit,upperlimit,tootoxic, toxcon, llactivity, number of simulations (sim)

simData

simNo,doselevel,stox (no of subjects experiencing activity),dllength (length of the cohort),toxl (lower 95% CI),toxu (upper 95% CI) ,toxCest (toxicity estimate)

DLdata

teqr.MTDdatatox takes the simData and DLdata output and creates the MTD level data.

design

The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design  is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.

teqr.MTDdataconACT: teqrOCact intermediate file that creates MTD/RP2D level data

Description

Usage

Arguments

References