tronco.bootstrap

The output of tronco.capri or 
tronco.caprese

reconstruction

Parameter to define the type of sampling 
to be performed, e.g., non-parametric for uniform sampling.

type

Number of bootstrap sampling to be performed 
when estimating the model confidence.

nboot

Percentage of cores to use
coresRate * (numCores - 1)

cores.ratio

A parameter to disable/enable verbose messages.

silent


Bootstrap a reconstructed progression model



The TRONCO (TRanslational ONCOlogy) R package collects algorithms to infer
progression models via the approach of Suppes-Bayes Causal Network, both
from an ensemble of tumors (cross-sectional samples) and within an individual
patient (multi-region or single-cell samples). The package provides parallel
implementation of algorithms that process binary matrices where each row
represents a tumor sample and each column a single-nucleotide or a structural
variant driving the  progression; a 0/1 value models the absence/presence of
that alteration in the sample. The tool can import data from plain, MAF or
GISTIC format files, and can fetch it from the cBioPortal for cancer genomics.
Functions for  data manipulation and visualization are provided, as well as
functions to import/export such data to other bioinformatics  tools for, e.g,
clustering or detection of mutually exclusive alterations. Inferred models can be
visualized and tested for their confidence via bootstrap and cross-validation.
TRONCO is used for  the implementation of the Pipeline for Cancer Inference.

Giulio Caravagna 
Alex Graudenzi alexgraudenzidiscounimibit
Daniele Ramazzotti danieleramazzottidiscounimibit

TRONCO


An R package for the inference of cancer progression models from heterogeneous genomic data

TRONCO, an R package for TRanslational ONCOlogy

tronco.bootstrap function

Bootstrap a reconstructed progression model

tronco.bootstrap: tronco bootstrap

Description

Usage

Arguments

Value

Examples