PermP

Calculates permutation p-values for location and RMST estimates.

Performs maximum likelihood based estimation and inference on time to event data, possibly subject to non-informative right censoring. FitParaSurv() provides maximum likelihood estimates of model parameters and distributional characteristics, including the mean, median, variance, and restricted mean. CompParaSurv() compares the mean, median, and restricted mean survival experiences of two treatment groups. Candidate distributions include the exponential, gamma, generalized gamma, log-normal, and Weibull.

Zachary McCaw

Temporal

Parametric Time to Event Analysis

PermP function

<dl><dt>df1</dt>
<dd>Target data.frame containing time and status.</dd>
<dt>df0</dt>
<dd>Reference data.frame containing time and status.</dd>
<dt>fit0</dt>
<dd>Fitted parametric survival distribution for arm 0.</dd>
<dt>fit1</dt>
<dd>Fitted parametric survival distribution for arm 1.</dd>
<dt>eps</dt>
<dd>Tolerance for Newton-Raphson iterations.</dd>
<dt>init1</dt>
<dd>Initial parameter values for the target group.</dd>
<dt>init0</dt>
<dd>Initial parameter values for the reference group.</dd>
<dt>maxit</dt>
<dd>Maximum number of Newton-Raphson iterations.</dd>
<dt>reps</dt>
<dd>Number of permutation replicates.</dd>
<dt>tau</dt>
<dd>Optional truncation times for calculating RMST.</dd></dl>

Arguments

Permutation P Value — PermP

<dl>

<dt>df1</dt>
<dd>Target data.frame containing time and status.</dd>


<dt>df0</dt>
<dd>Reference data.frame containing time and status.</dd>


<dt>fit0</dt>
<dd>Fitted parametric survival distribution for arm 0.</dd>


<dt>fit1</dt>
<dd>Fitted parametric survival distribution for arm 1.</dd>


<dt>eps</dt>
<dd>Tolerance for Newton-Raphson iterations.</dd>


<dt>init1</dt>
<dd>Initial parameter values for the target group.</dd>


<dt>init0</dt>
<dd>Initial parameter values for the reference group.</dd>


<dt>maxit</dt>
<dd>Maximum number of Newton-Raphson iterations.</dd>


<dt>reps</dt>
<dd>Number of permutation replicates.</dd>


<dt>tau</dt>
<dd>Optional truncation times for calculating RMST.</dd>

</dl>

PermP: Permutation P Value

Description

Usage

Value

Arguments