linear_accrual

rampupt

<p>The acceleration of the accrual rate (increase of each time unit).</p>

acceleration

<p>simulate accrual time where the accrual rate is linearly increased</p>

A system to simulate clinical trials with time to event endpoints. Event simulation is based on Cox models allowing for covariates in addition to the treatment or group factor. Specific drop-out rates (separate from administrative censoring) can be controlled in the simulation. Other features include stratified randomization, non-proportional hazards, different accrual patterns, and event projection (timing to reach the target event) based on interim data.

Bo Zhang

TwoArmSurvSim

Simulate Survival Data for Randomized Clinical Trials

Yi Zhong

Ginny Peng

Bin Yao

linear_accrual function

Simulate Accrual Time Where the Accrual Rate is Linearly Increased — linear_accrual

Simulate Accrual Time Where the Accrual Rate is Linearly Increased

linear_accrual: Simulate Accrual Time Where the Accrual Rate is Linearly Increased

Description

Usage

Arguments

Examples