trial_data_simulation

A data frame contains simulated survival time and censor status.

simdata

accrual

Target number of events of the trial

eventtarget

The maximum follow up time for the last enrolled patient.

maxlpfollowup

Simulate clinical trial by adding accrual time to the simulated survival data. And cut the trial at the target event time or at the maximum follow up time

A system to simulate clinical trials with time to event endpoints. Event simulation is based on Cox models allowing for covariates in addition to the treatment or group factor. Specific drop-out rates (separate from administrative censoring) can be controlled in the simulation. Other features include stratified randomization, non-proportional hazards, different accrual patterns, and event projection (timing to reach the target event) based on interim data.

trial_data_simulation: Simulate Clinical Trial with Accrual Time and Trial Stop Rules

Description

Usage

Arguments