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UBCRM (version 1.0.2)

Functions to Simulate and Conduct Dose-Escalation Phase I Studies

Description

Two Phase I designs are implemented in the package: the classical 3+3 and the Continual Reassessment Method. Simulations tools are also available to estimate the operating characteristics of the methods with several user-dependent options.

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Version

Install

install.packages('UBCRM')

Monthly Downloads

635

Version

1.0.2

License

GPL (>= 2)

Maintainer

Christophe Zemmour

Last Published

May 16th, 2022

Functions in UBCRM (1.0.2)

sim3p3

Simulation of one dose-escalation study with the classical 3+3 design
Crm

Dose-escalation with the Continual Reassessment Method
aip

Functions to calculate the appropriate dose level singletons
simCrm

Simulation of one dose-escalation study with the Continual Reassessment Method
CreData

Creates a CRM dataframe
psip

Dose-Toxicity modelisation functions
Lp

Likelihood functions
fp

Density functions
ssim3p3

Simulation of n dose-escalation study with the 3+3 design
UBCRM-package

UBCRM is a package containing functions to simulate and conduct dose escalation phase I studies
ssimCrm

Simulation of n dose-escalation study with the Continual Reassessment Method
updata

Update the CRM dataframe after new patients' collected data
troisPtrois

Dose escalation with the 3+3 design