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UtilityFrailtyPH12 (version 1.0)

Implementing EFF-TOX and Monotone Utility Based Phase 12 Trials

Description

Contains functions for simulating phase 12 trial designs described by Chapple and Thall (2019) including simulation and the EFF-TOX trial and simulation and implementation of the U12 trial. Functions for implementing the EFF-TOX trial are found in the package 'Phase123'.

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Version

Install

install.packages('UtilityFrailtyPH12')

Monthly Downloads

17

Version

1.0

License

GPL-2

Maintainer

Andrew Chapple

Last Published

February 22nd, 2019

Functions in UtilityFrailtyPH12 (1.0)

Returns the desireability value of a dose.

Returns prior dose-specific means.

RunAdaptiveEFFTOX

Simulates replications from EFF-TOX phase 12 trial.

Gives the dose to assign the next patient cohort using monotone utility based phase 12 trial.

Simulates replications from the monotone utility based phase 12 trial.

Samples from the posterior of the utility based phase12 model.