fill(runif(5))
fill(runif(5), ncol = 3)
fill(runif(5), val = 1, ncol = 3)
# Generate eyes data for the examples below. Eyes are independent (OR=1).
nn <- 1000  # Number of people
eyesdata <- data.frame(lop = round(runif(nn), 2),
                       rop = round(runif(nn), 2),
                       age = round(rnorm(nn, 40, 10)))
eyesdata <- transform(eyesdata,
    mop = (lop + rop) / 2,        # Mean ocular pressure
    op  = (lop + rop) / 2,        # Value unimportant unless plotting
#   op  =  lop,                   # Choose this if plotting
    eta1 = 0 - 2*lop + 0.04*age,  # Linear predictor for left eye
    eta2 = 0 - 2*rop + 0.04*age)  # Linear predictor for right eye
eyesdata <- transform(eyesdata,
    leye = rbinom(nn, size = 1, prob = logit(eta1, inverse = TRUE)),
    reye = rbinom(nn, size = 1, prob = logit(eta2, inverse = TRUE)))
# Example 1
# All effects are linear
fit1 <- vglm(cbind(leye,reye) ~ op + age,
             family = binom2.or(exchangeable = TRUE, zero = 3),
             data = eyesdata, trace = TRUE,
             xij = list(op ~ lop + rop + fill(lop)),
             form2 =  ~ op + lop + rop + fill(lop) + age)
head(model.matrix(fit1, type = "lm"))   # LM model matrix
head(model.matrix(fit1, type = "vlm"))  # Big VLM model matrix
coef(fit1)
coef(fit1, matrix = TRUE)  # Unchanged with 'xij'
constraints(fit1)
max(abs(predict(fit1)-predict(fit1, new = eyesdata)))  # Predicts correctly
summary(fit1)
plotvgam(fit1, se = TRUE)  # Wrong, e.g., because it plots against op, not lop.
# So set op = lop in the above for a correct plot.
# Example 2
# Model OR as a linear function of mop
fit2 <- vglm(cbind(leye,reye) ~ op + age, data = eyesdata, trace = TRUE,
            binom2.or(exchangeable = TRUE, zero = NULL),
            xij   = list(op ~ lop + rop + mop),
            form2 =    ~ op + lop + rop + mop + age)
head(model.matrix(fit2, type = "lm"))   # LM model matrix
head(model.matrix(fit2, type = "vlm"))  # Big VLM model matrix
coef(fit2)
coef(fit2, matrix = TRUE)  # Unchanged with 'xij'
max(abs(predict(fit2) - predict(fit2, new = eyesdata)))  # Predicts correctly
summary(fit2)
plotvgam(fit2, se = TRUE)  # Wrong because it plots against op, not lop.
# Example 3. This model uses regression splines on ocular pressure.
# It uses a trick to ensure common basis functions.
BS <- function(x, ...)
  sm.bs(c(x,...), df = 3)[1:length(x), , drop = FALSE]  # trick
fit3 <- vglm(cbind(leye,reye) ~ BS(lop,rop) + age,
             family = binom2.or(exchangeable = TRUE, zero = 3),
             data = eyesdata, trace = TRUE,
             xij = list(BS(lop,rop) ~ BS(lop,rop) +
                                      BS(rop,lop) +
                                      fill(BS(lop,rop))),
             form2 = ~  BS(lop,rop) + BS(rop,lop) + fill(BS(lop,rop)) +
                        lop + rop + age)
head(model.matrix(fit3, type =  "lm"))  # LM model matrix
head(model.matrix(fit3, type = "vlm"))  # Big VLM model matrix
coef(fit3)
coef(fit3, matrix = TRUE)
summary(fit3)
fit3@smart.prediction
max(abs(predict(fit3) - predict(fit3, new = eyesdata)))  # Predicts correctly
predict(fit3, new = head(eyesdata))  # Note the 'scalar' OR, i.e., zero=3
max(abs(head(predict(fit3)) -
             predict(fit3, new = head(eyesdata))))  # Should be 0
plotvgam(fit3, se = TRUE, xlab = "lop")  # CorrectRun the code above in your browser using DataLab