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VNM (version 4.1)

Using V-algorithm and Newton-Raphson Method to Obtain Multiple-objective Optimal Design

Description

Using V-algorithm and Newton-Raphson method to obtain multiple-objective optimal design for estimating the shape of dose-response, the ED50 (the dose producing an effect midway between the expected responses at the extreme doses) and the MED (the minimum effective dose level) for the 2,3,4-parameter logistic models and for evaluating its efficiencies for the three objectives.

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Version

Install

install.packages('VNM')

Monthly Downloads

28

Version

4.1

License

GPL (>= 2)

Maintainer

Yarong Yang

Last Published

February 11th, 2016

Functions in VNM (4.1)

Deff

D-efficiency for 4-parameter logistic model.
MOPT

Identify multiple-objective optimal designs for estimating model parameters, ED50, MED.
S.Weight

Identify optimal weights for given dose levels.
PAR

Class to contain the variables for the verification plots from function MOPT, ceff1, ceff2, and Deff.
OPT

Class to contain the results from function MOPT, ceff1, ceff2, and Deff.
ceff1

Checking c-efficiency for estimating the ED50.
VNM-package

Using V-algorithm and Newton-Raphson Method to Obtain Multiple-objective Optimal Design.
SW

Class to contain the results from function S. Weight.
ceff2

Checking c-efficiency for estimating the MED.
summary-methods

Methods to print SW objects or the optimal design and the efficiency from OPT objects.
plot-methods

Methods to plot the verification plot of the obtained optimal design.