PAR-class

For function MOPT, ceff1, ceff2, and Deff, the plot of the sensitivity function over the given
dose interval can be used to verify the optimality of the obtained design. Class PAR is used to contain the variables for the plot.

classes

Provide tools for finding multiple-objective optimal designs for
estimating the shape of dose-response, the ED50 (the dose producing an effect
midway between the expected responses at the extreme doses) and the MED (the
minimum effective dose level) for the 2,3,4-parameter logistic models and for
evaluating its efficiencies for the three objectives. The acronym VNM stands
for V-algorithm using Newton Raphson method to search multiple-objective
optimal design.

Yarong Yang

Finding Multiple-Objective Optimal Designs for the 4-Parameter
Logistic Model

PAR function

new("PAR",fid="character",LB="numeric",UB="numeric",grid="numeric",ds="vector")

Objects from the Class

<dl class="dl-horizontal">
 <dt><code>fid</code>:</dt><dd>A character showing the name of the function from where the four arguments are.</dd>
 <dt><code>LB</code>:</dt><dd>A numeric number showing the predetermined lower bound of the dose range for the log dose.</dd>
 <dt><code>UB</code>:</dt><dd>A numeric number showing the predetermined upper bound of the dose range for the log dose.</dd>
 <dt><code>grid</code>:</dt><dd>A numeric number showing the grid density to discretize the predetermined dose interval.</dd>
 <dt><code>ds</code>:</dt><dd>A numeric vector represents the values of criterion (an absolute value of the difference between the sensitivity function and 1) computed at each iteration.</dd>
 </dl>

Slots

Class to contain the variables for the verification plots from function MOPT, ceff1, ceff2, and Deff. — PAR

<dl class='dl-horizontal'>
 <dt><code>fid</code>:</dt><dd>A character showing the name of the function from where the four arguments are.</dd>
 <dt><code>LB</code>:</dt><dd>A numeric number showing the predetermined lower bound of the dose range for the log dose.</dd>
 <dt><code>UB</code>:</dt><dd>A numeric number showing the predetermined upper bound of the dose range for the log dose.</dd>
 <dt><code>grid</code>:</dt><dd>A numeric number showing the grid density to discretize the predetermined dose interval.</dd>
 <dt><code>ds</code>:</dt><dd>A numeric vector represents the values of criterion (an absolute value of the difference between the sensitivity function and 1) computed at each iteration.</dd>
 </dl>

PAR: Class to contain the variables for the verification plots from function MOPT, ceff1, ceff2, and Deff.

Description

Arguments

Objects from the Class

Slots

Examples