loadLd

An input file. Must be a raggr generated csv file or a bed file. If a bed file, it must contain at least five columns: chr, start, end, LD_snp_id, tag_snp_id.

data

The type of input file. Must be "bed" or "raggr".

type


This function will load a raggr output csv or user defined bed file to GRanges object. It is recommended to generate a LD file using http://raggr.usc.edu. If you prefer to use other softwares to calculate LD SNPs (e.g., plink), please format the output to bed files. Please make sure that you use a cutoff of 0.8 for r2 value.


Granges

raggr

Calculates the enrichment of associated variant set (AVS) for an array of genomic regions. The AVS is the collection of disjoint LD blocks computed from a list of disease associated SNPs and their linked (LD) SNPs. VSE generates a null distribution of matched random variant sets (MRVSs) from 1000 Genome Project Phase III data that are identical to AVS, LD block by block. It then computes the enrichment of AVS intersecting with user provided genomic features (e.g., histone marks or transcription factor binding sites) compared with the null distribution.

loadLd: loadLd

Description

Usage

Arguments

Examples